Sample Processing & Coating

HPH

High Pressure Homogenizer

A high-pressure homogeniser forces a liquid through a narrow valve gap to break droplets, particles and cells down to a fine, uniform size. It is used to make nanoemulsions, stable dispersions and cell lysates.

1 test optionPressures up to ~1,500 barSub-micron dropletsTypical turnaround 3–5 working days
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HPH processIllustrative
Coarse samplePressurePiston pumpHomogenising valveNarrow gapFine emulsionDroplet size
Pressure, a narrow gap, and finer dropsIllustrative
01 / Overview

What is HPH?

A piston pump pressurises the liquid, typically to several hundred or over a thousand bar, and forces it through an adjustable gap only micrometres wide. Intense shear, turbulence and cavitation in the gap break droplets, agglomerates and cells apart; repeated passes narrow the size distribution further.

Compared with stirring or an ultrasonic probe, homogenisation treats the whole volume evenly and scales from lab batches towards production, which makes it the usual route to nanoemulsions, liposomes and bulk cell disruption.

02 / How it works

How it works

  1. 01

    Sample is loaded

    The liquid sample or pre-mixed coarse emulsion is poured into the feed reservoir.

  2. 02

    Pressure builds

    A piston pump pressurises the liquid, typically to several hundred or over a thousand bar.

  3. 03

    Forced through the gap

    The liquid shoots through a narrow valve gap, where shear, turbulence and cavitation break it up.

  4. 04

    Passes are repeated

    The product is cooled and passed again until the target size is reached, then returned to you.

03 / What it measures

What it measures

Nanoemulsions

Break oil droplets down to a fine, uniform size.

Useful forPharma, food and cosmetic emulsions

Dispersions & deagglomeration

Break up clusters and spread solids evenly through a liquid.

Useful forSuspensions, pigments, nanomaterials

Cell disruption

Rupture bacteria, yeast or algae to release their contents.

Useful forProtein, enzyme and metabolite extraction

Liposomes & lipid nanoparticles

Reduce vesicle size and narrow the size distribution.

Useful forDrug delivery formulations

Uniform, stable products

A narrower size distribution slows creaming and settling.

Useful forBeverages, creams, dairy-type emulsions
04 / Test options

Choose the HPH options you need

1 option · none added yet

HPH test options
05 / Sample requirements

Sample requirements

Accepted forms
Pre-mixed emulsions, suspensions and cell suspensions
Volume
Typically at least 100–200 mL per sample
Feed particle size
Pourable, with no lumps or fibres (roughly under 100 µm)
Solvent
Water-based preferred; organic solvents only after confirmation
  • Pre-mix coarse emulsions with a stirrer or rotor–stator mixer
  • Share the target pressure, number of passes and temperature limits
  • Filter out lumps, fibres or large particles
  • No flammable solvents without prior approval
  • No pathogenic or unassessed biological material

Hazardous or air-sensitive samples: mention it in your request, and attach the MSDS if you have one.

06 / Results & turnaround

Results & turnaround

What you receive

  • Processed sample returned in sealed containers
  • Record of pressure, passes and outlet temperature
  • Process notes and observations
  • Size data if particle size analysis is also ordered
  • Report PDF

Turnaround & pricing

Typically 3–5 working days after samples reach the lab.

Price confirmed in your quotation, depending on user type, options and number of samples.

Sample report · IllustrativeExample mean droplet size185 nmIllustrative — not measured sample data
07 / Limitations

When HPH isn't the right fit

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